Data on nephroprotective effect of all-trans retinoic acid in early diabetic nephropathy
نویسندگان
چکیده
منابع مشابه
All-Trans Retinoic Acid Has a Potential Therapeutic Role for Diabetic Nephropathy
PURPOSE The aim of this study was to examine the effects of all-trans retinoic acid (ATRA) on diabetic nephropathy. MATERIALS AND METHODS We measured amounts of urinary albumin excretion (UAE) after administrating ATRA to Otsuka Long-Evans Tokushima Fatty (OLETF) rats. In order to understand the mechanism of action for ATRA, we administrated ATRA to examine its inhibitory action on the produc...
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Introduction: Previous studies have shown that vitamin A and its derivatives such as retinoid and all-trans retinoic acid have a crucial role in memory, learning and synaptic plasticity. The receptors of vitamin A are seen in different parts of the brain such as hippocampus, where vitamin A has an important role in learning. In this study, the effect of intrahippocampal (CA1) injection of al...
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A quantitative determination of physiological levels of all-trans-retinoic acid (vitamin A acid) in human serum has been developed. A double-phase extraction of 3.5 ml of serum followed by a specific and sensitive high performance liquid chromatography procedure allowed measurement of levels down to 1 ng/ml. Serum concentrations in 37 fasting volunteers ranged from 2.7 to 4.2 ng/ml and fitted a...
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Although the pathogenetic mechanism of diabetic nephropathy has not been elucidated, an inflammatory mechanism has been suggested to contribute to its progression. Monocyte chemoattractant peptide (MCP)-1 attracts macrophages and T cells, and ultimately injures renal tissue. In early diabetic nephropathy, urinary excretion of MCP-1 was elevated, and increased as renal damage became more severe....
متن کاملProphylactic effect of all-trans retinoic acid in an amyloid-beta rat model of Alzheimer\'s disease
Introduction: Retinoid signaling has been argued to have favorable effects on Alzheimer's disease (AD). We studied the role of chronic intracerebroventricular (ICV) injection of all-trans retinoic acid (ATRA) on the amyloid-beta (Aβ) model of AD. Methods: Adult male rats weighing 260-330 g were divided into 12 groups of 8 each. Six groups of rats received ATRA (3nM, 30nM, 3μM, 0.3mM, 30...
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ژورنال
عنوان ژورنال: Data in Brief
سال: 2018
ISSN: 2352-3409
DOI: 10.1016/j.dib.2018.08.080